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KMID : 0355620170430020063
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2017 Volume.43 No. 2 p.63 ~ p.69
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The role of nuclear factor I-C in tooth and bone development
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Roh Song-Yi
Park Joo-Cheol
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Abstract
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Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Kruppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
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KEYWORD
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Nuclear factor I-C, Dentinogenesis, Osteogenesis, Osteoporosis
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